:root{--flow-accent:#6557d9;--flow-accent-dark:#4f43bb;--flow-accent-soft:#f0eeff;--flow-ink:#172337;--flow-muted:#667286;--flow-line:#e3e7ed;--flow-bg:#f6f7f9;--flow-white:#fff;--flow-success:#208b70;--flow-danger:#bc4f55;--flow-shadow:0 22px 60px #1a223b17}*{box-sizing:border-box}html{scroll-behavior:smooth}body.flow-page{min-height:100vh;color:var(--flow-ink);background:var(--flow-bg);-webkit-font-smoothing:antialiased;margin:0;font-family:DM Sans,sans-serif}a{color:inherit;text-decoration:none}button,input,textarea{font:inherit}.flow-container{width:min(1160px,100% - 40px);margin:0 auto}.flow-header{z-index:30;border-bottom:1px solid var(--flow-line);-webkit-backdrop-filter:blur(18px);backdrop-filter:blur(18px);background:#ffffffeb;position:sticky;top:0}.flow-nav{justify-content:space-between;align-items:center;gap:24px;min-height:72px;display:flex}.flow-brand{letter-spacing:-.5px;align-items:center;gap:11px;font-family:Manrope,sans-serif;font-size:16px;font-weight:800;display:inline-flex}.flow-brand-mark{color:#fff;background:var(--flow-accent);border-radius:10px;place-items:center;width:36px;height:36px;font-size:11px;display:grid;box-shadow:0 8px 18px #6557d938}.flow-nav-actions{align-items:center;gap:18px;display:flex}.flow-nav-link{color:var(--flow-muted);font-size:13px;font-weight:700}.flow-button{cursor:pointer;border:1px solid #0000;border-radius:10px;justify-content:center;align-items:center;gap:8px;min-height:46px;padding:0 20px;font-size:13px;font-weight:700;transition:transform .2s,box-shadow .2s,border-color .2s;display:inline-flex}.flow-button:hover{transform:translateY(-1px)}.flow-button:disabled{cursor:not-allowed;opacity:.48;transform:none}.flow-button-primary{color:#fff;background:var(--flow-accent);box-shadow:0 11px 24px #6557d938}.flow-button-primary:hover{background:var(--flow-accent-dark);box-shadow:0 14px 28px #6557d947}.flow-button-secondary{color:var(--flow-ink);background:#fff;border-color:#d9dde5}.workflow-progress{border-bottom:1px solid var(--flow-line);background:#fff}.workflow-progress-inner{grid-template-columns:repeat(6,1fr);align-items:center;width:min(1160px,100% - 40px);min-height:44px;margin:0 auto;display:grid}.workflow-step{color:#9aa3b0;align-items:center;gap:7px;min-width:0;display:flex;position:relative}.workflow-step:not(:last-child):after{content:"";z-index:0;background:#dfe3e9;height:1px;position:absolute;top:11px;left:26px;right:8px}.workflow-step-number{z-index:1;background:#fff;border:1px solid #d8dde5;border-radius:50%;flex:0 0 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100px}.flow-page-heading{max-width:760px;margin-bottom:35px}.flow-kicker{color:var(--flow-accent);letter-spacing:1.4px;margin:0 0 11px;font-size:10px;font-weight:800}.flow-page-heading h1{letter-spacing:-2px;margin:0;font-family:Manrope,sans-serif;font-size:clamp(34px,4vw,49px);line-height:1.12}.flow-page-heading>p:last-child{color:var(--flow-muted);margin:15px 0 0;font-size:15px;line-height:1.7}.flow-panel{border:1px solid var(--flow-line);box-shadow:var(--flow-shadow);background:#fff;border-radius:18px;padding:36px}.pico-grid{grid-template-columns:repeat(2,1fr);gap:18px;display:grid}.pico-field{background:#fff;border:1px solid #dfe3e9;border-radius:13px;padding:20px 20px 17px;transition:border-color .2s,box-shadow .2s;position:relative}.pico-field:focus-within{border-color:var(--flow-accent);box-shadow:0 0 0 4px #6557d914}.pico-letter{width:28px;height:28px;color:var(--flow-accent);background:var(--flow-accent-soft);border-radius:8px;place-items:center;font-size:11px;font-weight:800;display:grid;position:absolute;top:17px;right:17px}.pico-field label{margin-bottom:8px;font-family:Manrope,sans-serif;font-size:14px;font-weight:800;display:block}.pico-field input{width:calc(100% - 38px);color:var(--flow-ink);background:0 0;border:0;outline:0;padding:0;font-size:14px}.pico-field input::placeholder{color:#a5adba}.flow-section-title{margin:34px 0 8px;font-family:Manrope,sans-serif;font-size:18px}.flow-section-note{color:var(--flow-muted);margin:0 0 18px;font-size:12px;line-height:1.6}.database-grid{grid-template-columns:repeat(3,1fr);gap:10px;display:grid}.database-option{cursor:pointer;color:#4f5c70;background:#fafbfc;border:1px solid #e0e4ea;border-radius:10px;flex-wrap:wrap;align-items:center;gap:10px;min-height:49px;padding:0 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#dce1e8;border-radius:9px;min-height:40px;font-size:11px;font-weight:800}.decision-button.include{color:var(--flow-success)}.decision-button.exclude{color:var(--flow-danger)}.decision-button.include.is-selected{color:#fff;border-color:var(--flow-success);background:var(--flow-success)}.decision-button.exclude.is-selected{color:#fff;border-color:var(--flow-danger);background:var(--flow-danger)}.results-footer{z-index:20;border:1px solid var(--flow-line);-webkit-backdrop-filter:blur(14px);backdrop-filter:blur(14px);background:#fffffff0;border-radius:14px;justify-content:space-between;align-items:center;gap:20px;margin-top:24px;padding:16px 18px;display:flex;position:sticky;bottom:0;box-shadow:0 -8px 30px #1e264214}.selection-summary{color:var(--flow-muted);font-size:12px}.selection-summary strong{color:var(--flow-ink)}body.professional-flow #app-container{margin-top:44px;height:calc(100vh - 44px)!important}body.professional-flow 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h1{font-size:33px}.database-grid{grid-template-columns:1fr}.flow-form-actions{flex-direction:column;align-items:stretch}.flow-form-actions-right{flex-direction:column}.flow-button{width:100%}.results-toolbar{flex-direction:column;align-items:flex-start}.article-card{padding:19px}.article-actions{flex-direction:column}.results-footer{flex-direction:column;align-items:stretch}.results-footer .flow-button{width:100%}body.professional-flow #app-container{margin-top:44px;height:calc(100vh - 44px)!important}body.professional-flow .extraction-progress{height:44px}.workflow-progress-inner{min-height:44px}}.article-title-button{cursor:pointer;width:100%;color:var(--flow-ink);text-align:left;font:inherit;line-height:inherit;background:0 0;border:0;padding:0}.article-title-button:hover{color:var(--flow-accent-dark);text-underline-offset:4px;text-decoration:underline}.article-title-button:focus-visible{outline-offset:4px;border-radius:4px;outline:3px solid #6557d933}body.study-modal-open{overflow:hidden}.study-modal[hidden],.study-full-text-section[hidden]{display:none}.study-modal{z-index:100;-webkit-backdrop-filter:blur(8px);backdrop-filter:blur(8px);background:#13192a94;place-items:center;padding:24px;display:grid;position:fixed;inset:0}.study-modal-dialog{background:#fff;border:1px solid #ffffffb8;border-radius:20px;flex-direction:column;width:min(1040px,100%);max-height:min(820px,100vh - 48px);display:flex;overflow:hidden;box-shadow:0 34px 90px #12182d47}.study-modal-header{border-bottom:1px solid var(--flow-line);background:linear-gradient(#fff,#fbfaff);flex:none;justify-content:space-between;align-items:flex-start;gap:28px;padding:25px 27px 21px;display:flex}.study-modal-heading{min-width:0}.study-modal-heading .flow-kicker{margin-bottom:7px}.study-modal-heading h2{letter-spacing:-.6px;max-width:720px;margin:0;font-family:Manrope,sans-serif;font-size:clamp(20px,2.4vw,28px);line-height:1.25}.study-modal-meta{color:#687386;margin:10px 0 0;font-size:12px;line-height:1.55}.study-modal-identifiers{color:#949dac;margin:5px 0 0;font-size:10px}.study-modal-tools{flex:none;align-items:center;gap:8px;display:flex}.study-modal-tools-label{color:#8a93a4;letter-spacing:.9px;margin-right:3px;font-size:9px;font-weight:800}.pico-modal-buttons{gap:5px;display:flex}.pico-modal-button,.study-modal-close{cursor:pointer;width:34px;height:34px;color:var(--flow-accent-dark);background:#fff;border:1px solid #dddff0;border-radius:9px;place-items:center;font-size:11px;font-weight:800;transition:border-color .18s,background .18s,color .18s,transform 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